Omeprazole is an extra-label drug (off-label) medication used to reduce acid in your dog’s stomach and small intestine. As such, it can help with gastroesophageal reflux and gastric erosions or ulcers that might be caused by tumors, infections, or certain medications such as non-steroidal anti-inflammatory drugs (NSAIDs). It is sometimes part of a protocol to treat Helicobacter infections. You may see omeprazole listed as Prilosec (brand name).
Omeprazole Dosage for Dog
Omeprazole is given once a day. It’s usually best to give it in the morning an hour before your dog’s first meal. Some dogs don’t handle medication well on a totally empty stomach, so check with your veterinarian about giving a small amount of food with the medication if your dog vomits or acts nauseous.
The recommended dose is .25 to .5 mg or omeprazole per lb of weight once a day, but your veterinarian may adjust the dose for your dog depending on his overall health.
The medication comes as pills or capsules available OTC (over the counter), however, pills should not be crushed or cut due to the special protective coating to help the medication function best in the stomach, and capsules should not be opened for the same reason. Instead, your veterinarian may arrange to have it compounded to adjust the dose for your dog (especially very small or very large dogs) or have it made into an oral liquid or paste.
How Long to Give Omeprazole to Your Dog
Omeprazole should be given for the full amount of time your veterinarian recommends. If you miss a dose, just wait until the next morning to resume dosing.
Omeprazole can take a couple of days to become truly effective. It is not recommended for use beyond four to eight weeks. In addition, you should taper or wean your dog off this medication if it has been taken for more than a week or two. A sudden stop can lead to a rebound in acid production. Your veterinarian can help you with a dose-reduction schedule.
Side Effects of Omeprazole for Dogs
Being available OTC and having low risk for toxicity may suggest you can simply give it on your own. That is not a great idea! It should be given under veterinary supervision and guidance.
Side effects can include vomiting, diarrhea, intestinal gas, and a loss of appetite. These signs are usually mild but could mask signs of more serious illness.
A major potential problem with giving omeprazole is that it can interfere with other medications your dog may be taking. The list of drugs includes diuretics, some antibiotics and anti-fungals, medications for seizure control, thyroid medication, immunosuppressive drugs like cyclosporine, and some heart medications. Make sure your veterinarian is aware of any supplements, including herbal remedies your dog may be taking.
Caution is wise for dog with hepatic (liver) or renal (kidney) problems, although it can be helpful for both of those conditions. Dosages may need to be adjusted for these dogs or omeprazole avoided altogether.
