Whole Dog Journal's Blog December 23, 2013

Trifexis and Adverse Effects

Posted at 05:08PM - Comments: (51)

Trifexis is a popular flea control medication which is known to cause severe reactions in many dogs. Here's what you need to know.

[Updated June 15, 2017]

A few weeks ago, the talk of the dog-related section of the Internet was Trifexis, the oral flea-control medication introduced a year or so ago by Elanco Animal Health. News reports alleged that more than 700 dogs have been killed by adverse reactions to this drug.

To verify that number, I looked to the FDA’s Center for Veterinary Medicine (CVM), the agency responsible for collecting and analyzing reports of adverse effects of veterinary drugs on animals. (Trifexis is an oral medication with a systemic activity. As I reported in the January issue of WDJ, systemically active insecticides and other oral medications meant for use in dogs are regulated as “drugs” by FDA CVM; in contrast, most topical pesticides are regulated in the U.S. by the Environmental Protection Agency (EPA). The notable exceptions are Advantage Multi and Revolution; their ability to kill the L3 and L4 [larval] stages of heartworm and intestinal worms is due to a systemic action, so they are regulated by the FDA.)

The CVM maintains an “adverse drug event” (ADE) database in order “to provide an early warning or signaling system to CVM for adverse effects not detected during pre-market testing of FDA-approved animal drugs and for monitoring the performance of drugs not approved for use in animals.” CVM scientists use the ADE database to make decisions about product safety, which may include changes to the label or other regulatory action.

Analysis of the CVM ADE reports involving Trifexis are made more complicated than usual because the CVM is transitioning from compiling data from reports received on paper to an all-electronic reporting system, and the release of Trifexis occurred in the middle of that process. Some of the reports have been captured by the paper process, and some by the electronic process.

Jim Strickland, a reporter for a TV news station in Atlanta, WSB-TV 2, has been following the story closely, after he received reports from local dog owners about dogs who died following the administration of Trifexis. He was able to obtain both sets of CVM ADE reports, containing data as current as November 14, 2013, concerning Trifexis. (Here is a link to Strickland’s story, which contains links to those ADE reports.)

If you look at the reports and do some addition, you will see that indeed, there have been about 660 dog deaths reported to the CVM by owners and veterinarians who were concerned that a previous administration of Trifexis might have been involved or solely responsible. (About 392 of those were listed as “death”; 259 were “death by euthanasia.”)

But the main thing that struck me as I was looking at the reports is -- what a mess the reporting system is! Also, that there is no end to the ways that humans can screw up the administration of medications – so, there is also no end to the ways that they can screw up the reporting of adverse events.

Contained within the reports are statistics for side effects that cats (and even one fish) suffered when administered this canine medication; side effects suffered by dogs where the route of administration was “intraocular” or “ophthalmic” (both words would suggest the tablet was somehow put in the dog’s eyes) or cutaneous (on the dog’s skin); many reports in which the route of administration was not included at all; side effects suffered by humans who consumed the medication; and even side effects suffered by humans who suspected that getting the tablet on their skin was the cause.

Then there are the problems related to language. Symptoms don’t get properly tallied because various words are used to describe what is certainly the same thing: “emesis” in some reports, “vomiting” in others; “lack of efficacy” in some, “ineffectiveness” in others; “decreased appetite,” “not eating,” “anorexia”...the list goes on and on.

While the “paper reporting” system is older, it appears to be more accurate in these tallies, probably because CVM vets are reading the reports and translating some of these various terms into more consistent language.

The symptoms and numbers tallied in these reports can be alarming, but some perspective is needed. Along with the reports released to the WSB-TV reporter, the CVM released a statement that contained language (also found elsewhere on its website) that cautioned readers to infer too much from raw data:

“When reviewing the cumulative summaries listing, the reader should be aware that:

• For any given ADE report, there is no certainty that the reported drug caused the adverse event. The adverse event may have been related to an underlying disease, using other drugs at the same time, or other non-drug related causes. The cumulative summaries listing does not include information about underlying diseases, other drugs used at the same time, other non-drug related causes, or the final outcome of the reaction. [Editor’s note: In other words, some of these dogs should not have been given the drug, due to known adverse drug interactions or other contraindications.]

• The accuracy of information regarding the ADE is dependent on the quality of information received from the veterinarian or animal owner.

• Accumulated ADE reports should not be used to calculate incidence rates or estimates of drug risk, because there is no accurate way to determine how many animals were given the drug, which is needed as the denominator in calculations of incidence and relative risk.

• Underreporting occurs with most adverse event reporting systems. The frequency of reporting for a given drug product varies over time, and may be greater when the drug is newly marketed, or when media publicity occurs.”

The ADEs also do not specify whether the correct dosage was administered to the dog (was the Chihuahua given the German Shepherd’s pill by mistake? did the dog eat a whole package of the medication? Did the owner misunderstand the directions and feed the wrong number of pills?), or whether the dog was already old or ill or otherwise a poor candidate for the medication.

I’m definitely concerned about the ADE reports about Trifexis – one can’t help it, when imagining all the dogs suffering all the symptoms reported in the ADEs. I strongly encourage dog owners to report any adverse effects to the CVM – as accurately as possible! – if their dogs suffer an adverse reaction to Trifexis or any other medication. And I strongly advise dog owners to take heed of the warnings we gave in the January issue – pointers on how to safely administer Trifexis and any other topical or oral flea control medication or pesticide (including many tips on what dogs should not receive these medications, and how to use them as minimally as possible). But I also recommend that the numbers be taken with a grain of salt; it’s very, very raw data.

For in-depth advice on preventing fleas, read "Protecting Your Home from Fleas," (January 2014).

Comments (51)

On 02/09/19 I brought my 9 mo. Old pitbull Luna to the vet to get her nails clipped and get her 3rd monthly trifexis pill. Everything was normal ,got home gave it to her. She was running around barking ,playing then she laid down about an HR after giving her pill and took a nap , 30 min later she made a snoreing sound her head went BK and she was dead. Her heart had stopped to signs of distress just gone. She was heathy . I wish I would have not given her the trifexis. I miss her greatly!

Posted by: Jason Maddox | February 11, 2019 9:13 AM    Report this comment

My nine year old Australian Shepard died recently of leukemia. He was in excellent health with 7 years of agility experience.
I had been giving him Trifexis for over three years with amazing results. He never vomited, convulsed or had any noticeable side effects. He did not like taking the pill.
I am writing in hopes that people will consider not giving this pill to their dog. I am concerned that it alters the biological and chemical makeup of our dog which makes them vulnerable to other diseases that have not been reported or tested.

Posted by: devery | May 14, 2018 11:07 PM    Report this comment

Our 13 month old, 12 1/2 pound Cavapoochon, Bella, has been on Trifexis for about a year. In February 2017, after having been given Trifexis about 5 hours earlier, we noticed sudden bizarre behavior--she was just staring at the ceiling and did not respond to her name. We took her to the emergency vet. She seemed to snap out of it by the time we got to the vet (about 4 miles away). After an examination during which they found all of her vitals were fine, the vet decided that she had experienced an allergic reaction to a cream we put on her after her bath. We had been using it since we got her and had used it that day but were happy to find it was nothing serious and threw the cream out. We continued her monthly dose of Trifexis. I do have to say it is possible she had the same reaction in subsequent months, but perhaps we were out of the room or it was while we were sleeping. Last Monday we gave her the usual dose. About 5 hours later I heard her barking and went to where she sleeps. I brought her back and put her on the bed and she again exhibited bizarre behavior. This time she kept wanting to get next to me, climbed on top of me in order to stare at the ceiling, and kept moving her mouth as if she were going to speak. Back to the emergency vet. We had no trouble walking her to the car and once again she snapped out of it by the time we got there. I mentioned that this was the second time this happened after Trifexis. The vet said that it is possible it was a reaction to Trifexis, but not likely. She thought it might have been a seizure. Once I heard that my brain almost shut down and I don't really remember the discussion about different types of seizures. The vety recommended some tests, but I decided to see our vet the next day. Our vet also said it was possible the Trifexis could have caused this behavior, but not a high probability. Her vitals were fine again. It was time for her wellness check so she did that and I asked that all blood/urine/feces tests be done. She also said we should take Bella off Trifexis and put her on two meds instead--one for heartworms and another for fleas/ticks. Two days later the vet called to say that all tests were fine but a slightly elevated thyroid (and asked if Bella was ever fed animal neck meat!--she has not. The doctor said to recheck her thyroid in three months but if I wanted it done sooner we could--and I do want it checked in a month. I also wonder if the Trifexis caused the elevation of the thyroid. Bella has been back to normal--playing the ball, splashing in her little pool, playing like crazy with another dog. Of course, I Googled Trifexis and have seen so many sites with negative posts about Trifexis. After posting on Facebook and talking to friends, I'm not even sure if Bella needs flea/tick meds. Many are suggesting holistic vets. I'm still a little nervous since I read that if she did have a seizure it may be that she has epilepsy. On the other hand, her symptoms didn't seem like a seizure to me, but rather a drug overdose as a human might experience. That's our story ~

Posted by: Sandy A | September 10, 2017 2:17 AM    Report this comment

Our female Boxer is 12 1/2 years old now, and of course we pander to her every need. She has been one of the greatest blessings of our lives since our kids left home.

She'd had a good day today, had been out in the heat a little bit, but mostly stayed in the cool. About 15 minutes ago, I heard a thud under the stairway where she likes to look out, and there she was with eyes glazes over, stiff legged and had urinated slightly on the floor. I got to her and turned her around, patted her a little and called her name, and slowly the tail began to wag and her eyes lit up again.

She was coughing slightly, I kept her still for a few minutes, then helped her get up when she was ready. She sort of looked around with a sheepish Boxer smile, like, "well, don't I feel foolish".

My wife and I began to compare notes, and it turns out she'd had a dose of Trifexis about an hour ago. She hates that pill anyway, so it will be given no longer.

Now, I have no way of knowing for sure about the pill, as she's had a few "tics" the recent past month. Eyes fluttering and sudden facial twitches, so I wasn't entirely surprised when I saw her today. However, my memory is that the twitches were concentrated around the time of what would likely have been her prior dose.

Whatever the case though, I believe our furry angel has enough challenges dealing with her advanced years without a surge of toxicity in her body. I believe that Trifexis was the trigger, and poses a larger threat to an older dog than what it tries to prevent. Perhaps we will find a milder solution, or maybe we'll not bother her with it at all.

Posted by: Trinchera | August 20, 2017 5:58 PM    Report this comment

To all pet owners with Trifexis adverse events please read: I recently brought in my 7 y.o. St. Bernard mix for check up and glazing over eye like cataract and sores near his tail with something poking out of them. He is bathed regularly and has been on Revolution since we got him 7 years ago. The vet thought we should start Trifexis as we live on Gulf Coast and heartworms are prevalent here. So we did. After first dose over two days, he started itching a great deal even though he has never had fleas, eye discharging and labored breathing even when sitting or laying inside previous. His cloudy eye became more cloudy also. My daughter and myself have also been having strange skin itching, lesions out of nowhere and irritated eyes for many months the doctors could not figure out. Decided to take him to a doggie ophthalmologist and I had been wiping his eye and looking in magnifying glass to see if I could see anything and saw white, clear and black threadlike strings and also noticed same things coming from his lesions. Turns out it is Onchocerciasis Lupi...related to heart worm nematode. These drugs kill too many larvae at once and can kill your pet. The blood test the vet does before starting heart worm preventative will not show larvae as they are usually in the eye, skin and sometimes spinal column and brain. Skin scrapings from neck back face nose area show highest concentrations of larvae but not always. Pet m.r.i.s are expensive, I know but if you notice itching with no fleas, eye cloudiness or discharge and are in heart worm area, this may be your dogs problem. Look up Zoonotic cases of O. Lupi. In Vet journals and you will get examples. It is hard to spot as the ones that exit through skin mix in with pet hair. This is occurring more and more in all areas of the U.S. Good luck. Treatment involves Doxycycline with occasional doses of Ivermectin with steroids if load high to prevent poisoning the pet from killing too many larvae at once, same as humans. This can kill your pet and or make it blind as the worm releases toxins around the eye in death causing the cataract look glaze over eye. I suspect this is the main cause of most pets severe reactions.

Posted by: Ginbrady | April 4, 2017 5:42 PM    Report this comment

I have a 6 y.o. Deutscher Wachtelhund who I have given Trifexis to for 6 years. She has been a very healthy dog with the exception of a mild seizure when she was 4. Last Thursday evening I gave her Trifexis and Friday evening she had a seizure that lasted for less than 2 minutes, came out of it, vomited, and had another seizure. The last one was not as severe lasting less than a minute. I took her to the emergency clinic and she was fine upon arrival, vitals were normal. The vet suggested I take her to our vet for blood work just to make sure her liver and kidneys were functioning normal. Blood test came back normal and she seems fine. I don't know if the seizure she experienced at 4 y.o. was near the time frame of her Trifexis dose. After reading comments I'm not taking any chances. Trifexis is history. And, to think I was considering going to 60 + pounds since she weighs 61.8. Luckily I was administering up to 60 pounds.

Posted by: Pktyroch@aol.com | February 7, 2017 6:44 PM    Report this comment

Add us to the list of long-time Trifexis users who've switched. Our Rott/Lab mix took it for over 4 years and all was well - no fleas, no worms. Then he dropped a couple of pounds (about 5 lbs), and his next dose made him a little "off" but nothing too obvious. After his last dose, however, I woke up in the night to notice he wasn't sleeping next to our bed like normal. Went into the living room to see him lying like a sphinx - upright and stiff, staring straight ahead. I tried to get him to move, but he couldn't bend his legs, and seemed unresponsive, though conscious. I carried him to the guest bed (he's a big dog), and he couldn't relax his neck muscles enough to lay his head down. I laid next to him and fell asleep and when I woke up a few hours later, he was ok. My vet tells me the seizure issue is with the flea meds in Trifexis, not the heartworm, so he put Alex on Sentinel, and we haven't had any issues since.

Posted by: Rottielab | October 21, 2016 2:43 PM    Report this comment

Seesm vets blow this off way too easily. if I have to take Tucker in and have him put down. Do not think the VET will like me after I explain the cause that he refuses to acknowledge

Posted by: n9lya | October 14, 2016 12:38 PM    Report this comment

Here is an email I had to send this morning Was Conversing with an adoption Agency however I do not think that is wise due to the dogs aggressive changes . Would not be fair even if explained to them in advance. No one can perceive this like I have.
>>Hi Heather.. I had never considered that he may be a mix? Possible.. I read Chihuahua's could weigh between 3 and 15 lbs.. But that was on the internet. Could be miss information..
Anyway let me give you some history and what we believe happened. To Cause his strange behaviour. Seeing how we observed the changes from a Happy never hostile petto a jekle and hyde..
When we first got him and upuntil about two years old my wife not only bonded with him, they were like soul mates. She was able to completely potty train him by the time he was six months old. We all got a long great anyone comes over they were always playing with him and holding him. My sister , and our daughter in law espeically.
Then came Tri-fexus or how ever you spell that poison.. he took one does and was acting all kinds of weird. Fo a day. Vet said we needed to feed him before we gave him that pill, we did and even mixed it with some canned dog food to make sure it did not upset his stomache and then he had this eqispode where he was unbalanced very lethargic and just plain ill.. Following the Experts opinion "our vet" we tried a second pill a month later as scheduled as he said he would probably be ok this time. Well he was worse could not walk for a day..
Ever since this he behaviour has been bad.. He is still loving most of the time. But not all the time, my sister has actually been bite (snapped at) and my daughter in law as well nolonger attempt to hold him.
He nolonger does perfect on the potty training often going inside the house. Reading up on this pill seems we are notthe only ones who had trouble.. When we refused to buy it and informed our vet about it they all got very hostile. The vet said he never had an issue.. and ssid his SALESMAN said all that is hype there is nothing wrong with Tri-Fexis. His Salesman.. I said.. really of course your SALESMAN would defend his product.. He has my wife convinced that when we are ready we can bring him in and have him put down..

So really I do not know what to do.> I either find him a home or I have to come home one day and find out my wife has taken him in... I know this is not your problem.. but thanks for listening...
My Dog to this day when he is not acting like he has no recolection of us.. is very loving to both of us.. And would jump infront of an intruder for us.. We both know that.. Its just he is unpredictable..
He is always happy to see us when we have been gone just do not really understand what has happened. But we are convienced it was thr tri-fexis...

I guess I know what I need to do to keep the peace. Being off work tomorrow.. I may have to and just chalk it up to another death by Tri-fexis. I do not want to isolate him to the garage this winter and how is that living...

I wish I could ask him how I should handle this..

Thanks Jerry

Posted by: n9lya | October 14, 2016 12:37 PM    Report this comment

So I just went through a terrifying couple of hours with my little mixed rescue who is a year and a half old. I have given all of my dogs Trifexis for years now and read up on Trifexis toxicity a year ago after hearing some bad stories. I spoke with my vet about my.concerns which were blown off. I gave all three dogs their monthly doses today and a few hours later one of my dogs freezes while standing, cannot move, when she tried to take a step she collapsed. I fell to the floor with her, holler for my son, I have her head in my lap but she could not move. Her body got cold like ice. We were frantically trying to think what she may have gotten into but came up with nothing. After a while it donned on me that she took the pill earlier and I knew EXACTLY what I was looking at.....Trifexis toxicity. She threw up a couple times and it smelled like the pill(awful smelli). I syringed some water down her throat to keep her hydrated. After an hour on the floor with her she finally started moving but she is extremely exhausted now. I bundled her up and watched her close for another hour and now she is conked out at my feet in bed for the night. I hope this nightmare is over and I will not be giving her this again. Here in the deep south the fleas are so bad and this is the only medsicine that ever fully worked. No idea what I will do now.

Posted by: robin2115 | May 5, 2016 12:33 AM    Report this comment

My 1 year old Schnoodle, Piper, has been on Trifexis since she was 3 months old without any reactions...until last night. I gave her the exact dosage prescribed, exactly how it was to be given and four hours later I am rushing her to the Emergency clinic. She was so out of it that i thought she was dying. No response to my voice and we are talking a normally bouncy very alert little dog reduced to a puddle of fur with her eyes closed and her head tilted back while making these strange yawning actions. The vet said that it was a reaction from the Trifexis and had I not brought her in when I did she would not have made it thru the day. Today she is lethargic, a little dehydrated and showing no desire to eat but I am hoping this too shall pass. I would warn anyone that loves their fur babies to find a different means to the pests that plague our pets. I know I will be.

Posted by: Christine R | March 1, 2016 3:15 PM    Report this comment

I thought this article was good and I just wanted to share my story:

I am happy to take in other stories and put them on this page too. My goal and intent is to take in factual cases, with some level of detail as to symptoms and diagnosis... but mostly as advice for other dog owners on things to consider, watch out for, be aware of, etc.

Posted by: Shawn3B | January 26, 2016 6:50 PM    Report this comment

I thought this article was good and I just wanted to share my story:


I am happy to take in other stories and put them on this page too. My goal and intent is to take in factual cases, with some level of detail as to symptoms and diagnosis... but mostly as advice for other dog owners on things to consider, watch out for, be aware of, etc.

Posted by: Shawn3B | January 26, 2016 6:48 PM    Report this comment

Just gave my 7 month energetic mini schnauzer Trifexis last night. After he took it he went to sleep normally he would want play time before bed. I didn't think anything of it because he had a long day but then at 1 am he threw up :/ the box said if he throws up within an hour to have your pup retake the pill but it was past an hour so I didn't give him another one. This morning he followed me around to house but didn't try to play like he normally does he just kept laying down. I tried to feed him before I left for work but he didn't take it. I gave him a treat and he ate but within 10 mins he threw that up. I'm having someone check up on him through out the day until I get home but I will be calling his vet to see what they say. I already don't like this pill

Posted by: Ashh | January 7, 2016 8:37 AM    Report this comment

Our 5 year old 15 pound Dachshund had a very bad reaction to this drug. Similar to what was described here. Lost the use of his back legs within 2-3 days of administering his dose. Would stare at the ceiling and tremble. Seemed to be in much pain. Second time this has happened and we just connected the issue to the drug use. Last time our vet was recommending surgery but his round of meds were a miracle. We are waiting now to get in to see our vet and are hopeful this will reverse again. We will NEVER use this drug for any pets again!

Posted by: Dallas Doxiex2 Mom | December 1, 2015 7:55 AM    Report this comment

I am posting this in the hope that it will help some of you and your dogs.

The ingredients in Trifexis are Milbemycin oxime and spinosad. Milbemycin oxime is very, very similar to moxidectin, which is also a milbemycin.

Moxidectin is the lead ingredient in Bayer's product - Advantage Multi.

My dog had a reaction to Advantage Multi that is almost identical to what you are describing here.

The drug was applied topically on Friday night, and by Monday night she had lost the use of her back legs. She stretched her neck (as many of you describe) and stared at the ceiling. Her whole body was stiff. She had tremors. Her personality changed and she became aggressive. By Tuesday morning she had lost the use of ALL her legs. I found her that morning on her side, screaming in fear. Her eyes would go back and forth from being dilated. She would not allow me to touch her. Any time she was touched she screamed.

This was on May 12.

What I want you to know is that these drugs have a very long half-life. Topically applied Moxidectin has a 35 day half-life. That means it takes about 6 months for it to be gone from the dog's system.

It took my dog months before she moved her legs. She regained functioning very, very slowly. First her front legs, then she could sit, then she regained control of her back legs, then she could stand. Now, five months later, she can walk awkwardly but she still cannot control her bladder and bowels.

The drug company will never admit fault. The vets will never admit it could be the drug's fault. My dog has had MRIs, X-rays, blood tests, abdominal ultrasounds etc...There is no structural abnormality. There is no alternative diagnosis.

My dog has nearly died on many occasions. Her inability to control urination has caused repeated bladder infections which have nearly killed her. Her inability to control her bowels has lead to chronic constipation and megacolon.

Please - if you are in this situation with your dog, get them on a laxative and a urinary supplement like D-mannose. Prevent these issues from starting, because once they start they are very costly.

The vets wanted me to euthanize her in May. They said she would never walk again. Now she walks and plays, but she is still not back to normal. I do believe she will regain functioning, it is just a matter of whether I can afford to keep her alive until then. Bayer will not help me, despite begging them for support.

If you are up for it, start tweeting with the hashtags #afteradvantage and #aftertrifexis. Tag #bayer and #elanco. If they won't help us, at least we can spread the word about their products and help other dogs.

You can email me at savespeckles at gmail.com. I would love to hear from you and share stories.

Warm wishes for the recovery of all of our babies.

Posted by: SaveSpeckles | October 1, 2015 2:28 PM    Report this comment

I just experienced the vomiting situation with my dog. He refuses to eat his food. (ex. I ask him does he want to eat and he'll take a kibble then spit it all on the floor). Not to bash Vet Drs. but I feel that they don't really care about our pets. Why can't they be honest and say this brand is new but because of side effects I recommend another brand or this works better for some dogs but the dosage may be too strong for your type of dog. My dog, Tyke, took Trifexis a year already and I now plan to switch him.

Just a little note, I feel because my dogs are inside dogs and I'm particular where I walk them, the Chowchow I had for 16yrs and old age issues did not take a Trifexis type of flea or tick med and she was never ill or had heart worms etcetera and every year she got her dog wellness exams, necessary shots with blood work. I made sure my GSD (9wks old at the time) has the works and now he will not eat, vomits and he just turned 1yr. old. Looking at these two scenarios I feel why am I paying all this money on my GSD and now he's sick.

Posted by: GSDlover | September 30, 2015 5:25 PM    Report this comment

My Brussels Griffon/Chihuahua mix got very lethargic, wouldn't eat and didn't want to go on walks after taking Trifexis. I didn't put 2 & 2 together until I figured out that she would get like this after I gave her Trifexis. I had her on it for 5 months in a row and every month, her symptoms lasted longer. I feel bad that it took me so long to realize what the problem was. I discontinued this medication and after being off it for a month, she's back to her old self. She's now on Revolution with no apparent side effects.

Posted by: Cher | September 29, 2015 9:21 PM    Report this comment

I'm an owner of a fairly new breed of dog...briewer Yorkshier terrier, Becca. I'm reaching out to the community here for help or advice. My ex vet gave my dog, who was born with microvascular liver dysplasia, trifexis. From the onset of the first dose for almost 2 years she was always sick. Vomiting, lethargic, drooling. He kept insisting that it wasn't the medicine that was making her sick. She was fine until after the first dose. Last summer I took her off trifexis myself but the damage was done. She ended up in the hospital a year ago for pancreatitis, and she is now a chronically ill dog. The ER vet changed her diet to Hills Science LD...but now for months she throws up every two weeks, and I'm ready to take legal action. I know (and so does her new vet) the liver so damaged from trifexis, and her first vet was so negligent, insisting in repeating doses a week after she threw up from her monthly dose! For two years! I feel so dumb I trusted my first vet!

Posted by: Mary Lou Alto | August 31, 2015 7:25 AM    Report this comment

I gave my Jack Russell Trifexis at my vet's recommendation. He became lethargic and wouldn't eat. When I took him back to the vet his liver tests all were extremely elevated to the point they thought he may have liver failure. They did not mention the Trifexis could be a cause and instead blamed his age (11). I stopped giving him the Trifexis after reading it may kill dogs. After about 6 months off the Trifexis he was back to his old self. Today I took him to the vet and his liver tests are all normal. Seems to me the medication is poison and Vets need to be more cautious about the meds they are pushing.

Posted by: SamsonRMom | April 28, 2015 12:46 PM    Report this comment

Trifexis is a horrible drug! We had been giving it to our adopted at age 8 Weimaraner, Winchee at the advice of our former vet. He had been on it for 2 years before he reacted violently. He had a violent seizure 2 hours after I gave it to him and another the next morning. This was in March and he has been slowly deteriorating ever since. Needless to say, he is no longer the same dog! I blame our vet and most vets out there who are all still prescribing Trifexis, and of course the ever greedy drug companies. We reported our incident to Elanco who was supposed to report it to the FDA... and recently found out they hadn't!!! Ooo big surprise there! You know the system is messed up when the drug companies are responsible for policing themselves! Please give me a break...what a JOKE!

Our dog is alive and that's about all. He seems to have irreversible neurologic damage. He no longer enjoys much of anything. He paces incessantly for hours if not distracted or encouraged to lay down. He sleeps when not pacing, probably from exhaustion. He now has to have a diaper.He has lost his ability to balance while riding in the car, which used to be the joy of his life. He no longer wants to go on walks, or run or play and he used to go on a 2 mile RUN with me every day. He is afraid of every little noise and nearly falls over when easily startled. He doesn't interact with other animals or people. He occasionally shakes and trembles while laying down due to fear and confusion. He is just the shell of the dog we once had!

He is going to a neurologist next week. (This will be the forth vet he's seen since his initial reaction in March.) It may seem cruel to some readers that we haven't put him to sleep. He is not suffering yet. We have run tests and the rest of his body seems to be running quite well (fortunately or unfortunately). Every once in a while he will be lucid and "remember" us. It usually lasts just a few minutes, but I am trying to have some hope and be with him when he is really "there". His eyes shine again, he gives kisses, he wags his tail! And then for no reason he is gone again. Maybe the neurologist will have some help for him...I have so lost faith in traditional vet care...it will take a miracle to win my trust back! A miracle is about what he needs!

Posted by: ra_nash | October 21, 2014 11:53 PM    Report this comment

I have been using Trifexis on my Aussie mix for a few years now. My dog goes to the vet regularly and even though he is on heart worm medication, he gets tested every 2 years. I have him test since heart worm medication do not quarntee he will not get them, but will reduce the risk. Until this morning, my dog has never had a reaction to trifexis. My dog acted as he had been paralized. I thought he was having a heart attack, stroke, or a seizure. Poor baby just could not walk or stand, nose pointed up at the ceiling. I called my vet right then and there and left a message about what I was observing. I was told to bring him in and they wanted to run some blood test and keep him for the day. My vet is smart and asked me why I was using trifexis. I told her that I was told by another vet that it was safe for my breed of dog and that some of the other heart worm meds could kill him. After leaving the vets office, I got home and jumped on the internet and did a little research. I learned that certain breeds have MDR1(Multi-Drug Resistance 1). It is a genetic defect in some breeds and can cause serve long term health problems and death in dogs when they are given certain types of drugs. Ivermectin is an ingredient found in Hear Guard that will also cause problems and death in dog breeds who test posited for MDR1. 1 out of every 2 Aussies and Aussie mix will have this mutated gene. My vet let me know that she is going to look for a alternative heart worm medication that would be safer for my Konner. Now I am left wondering if he is going to have any permanent side effects or long lasting health problems due to trifexis. If you are not sure if you dog has this gene, you can have them tested. You can go to vetmed.wsu.edu for more information. If you would like a complete list of drugs that can cause harm in dog breeds with MDR1, you can go to the same website and click on problems drugs on the left side of the page.

Posted by: Rose Ebel | October 15, 2014 10:47 AM    Report this comment

I am truly amazed with what I have been reading. I bought Trifexis for the first time for my pet, Kasey, the first Friday in September of 2014. Of course, the whole time thinking I was protecting her from fleas. By Sunday evening she began falling down every time she would attempt to stand up. Sadly, at first I thought she was just being herself and acting silly so I assumed that she had slipped on our wood flooring. It very soon became obvious that this was not anything silly at all. On Monday morning she was no better at all, and was breathing very heavily and held her head in a way that would make anyone think that she had suffered from a stroke. I took her to the vet and was told that she had hurt her back and that two of the vertebrae were pinched together. I certainly believed the vet and brought my girl back home with an antiflammatory medication. I was completely amazed to see her running around and acting like she was as good as new by the end of the month. Still believing that her back was hurt and that she was doing better, I unfortunately gave her the second dose of the medication in October still thinking that I was protecting her. This second dose was given on Sunday afternoon and again by Wednesday she was unable to walk again. This time she woke in the morning having vomited all over herself and had also had diahrrea that was also all over her. Kasey had never before gone to the restroom where she slept. I had been making her sleep in a cage in an attempt to keep her from jumping on one of our beds or something that we had assumed was the reason for her injured back. That morning she was completely unable to even stand up on her hind legs. I carried her outside and thought maybe she would feel better being out there for awhile while I cleaned up the mess inside. I was wrong, she could only lay out there in the grass. I ended up taking her to the vet (a different one this time) unfortunately afraid that she was going to have to be put to sleep. I spoke with the staff in the office and asked if Trifexis could be the cause of the awful condition that my poor girl was in. I told them everything that had been said at the previous vets office and everything that had happened at home since then. They said to me that the symptoms that I had described were not the symptoms of Trifexis and that her back condition was probably just reoccurring and due to her age (13) would most likely continue to happen. I said I just can't get over the fact that this seemed to be happening just as it had the month before and that even the number of days from the medication being taken to the first sign of problems was just about the same as well. I asked if they really felt that this was just coincidental and they did. I unfortunately believed them as they were the professionals in this matter and had my girl put to sleep. I spent the whole day feeling as though this was no coincidence so I began doing some research and found so many people describing situations much like our own. I wish to God that I had brought Kasey right back home with me and never given her another dose of this toxic medication again. I am now convinced that this drug was the cause of all of her symptoms and feel utterly responsible for her death. I pray that people do some research before considering this medication for their pet. This guilt is something that I will live with for the rest of my life and my goal is to make sure no one else has to ever feel the way I do right now. I called the vet back today after reading everything that I have read and was told that you have to be careful with what you read online. My response was that I understand that completely but find it totally impossible that I have read so many other people's accounts of their experiences that mimicked our own. This is not possible that we have all experienced such a tragedy and yet it is not true. I at first thought that maybe the vet and staff had no idea of the adverse symptoms but now am not so sure that its not just about making money.

Posted by: Kaseysmomma | October 10, 2014 7:54 PM    Report this comment

We have x2 young mini wiener (7 lbs) dogs and x1 12 yr old (21 lbs) tweenie. Our tiniest, Tinker Bell, Became very lethargic and wouldn't eat for 24 hours both times I gave them Trifexis. Both times she was obviously not herself for initial 24+ hours. They are in Florida and fleas are real problem most of the year. They have been flea free, but not worth the potential loss...we decided not to continue the treatment.

Posted by: KRRN | September 28, 2014 9:53 AM    Report this comment

I had to have my baby put down in November of 2013. I had given her trifexis about a week before that. I dont know if trifexis played a part in her passing (she had heart worms and a tick disease when i rescued her) but I know in my heart it didn't help. Now I live with the guilt and blame myself.

Posted by: dilbrycat | September 26, 2014 7:57 AM    Report this comment

The problem is that there are no case control scientific studies to answer this question, and unfortunately in the absence of these, veterinarians jump to the conclusion there is no relationship. True, pet owners get emotional and probably half of the reports could be dismissed because there just isn't enough evidence to show the link. But the sheer number of reports is definitely of concern. And I can't help but be struck by the similarity of symptoms in so many reports. And now I learn Elantra lists some of these as potential side effects. I can't comment on the deaths, but I just had an experience that left no doubt in my mind. I have two labs and a pug, and although only the one lab seemed to not be able to completely avoid fleas with the topical medications, my vet suggested a one month trial of Trifexis and since she would be on it, the other two should be as well. Within hours, the pug was having g.i. problems; by the next morning he was having non-stop diarrhea all over himself and wouldn't eat. I went out for 2 hours and when I returned, he had lost control of his hind legs. He was in terrible pain, making all kind of noises and weird contortions so I rushed him to the vet. This was a new vet I hadn't seen before and I was struck by her refusal to even consider Trifexis might have caused this, that the two symptoms could not be related at all, and that it was pure coincidence they happened at the same time, hours after the first dose of Trifexis. She took blood work and X-rays, and blamed the loss of rear leg function completely on two vertebrae that were somewhat pinched together. She pointed out all this (obvious) weakness, lameness, etc in the rear end and ignored my statements that he had never shown any of these symptoms before. She gave him narcotics for his pain and he slept all night. next day he ate a little and had regained the use of his hind legs, though he was not moving very fast. by the third day he was completely back to normal, eating normally, no lameness or weakness in his hind legs at all. There is no question the Trifexis caused the severe g.i. problems and pain and though I don't deny his pinched vertebrae played a role, I am convinced all the writhing and pain and straining from the g.i. problems triggered this spinal problem to surface. the fact that he had no such symptoms before the Trifexis, and 3 days later was also symptom free, tells me the pinched vertebrae alone did not cause the loss of his rear leg function. So many of these reports mentioned neurological problems and loss of hind leg movement. I just wish someone would do a scientific case control study on this. I think smaller dogs are particularly susceptible. One of my labs drooled the entire next day, a common symptom of poisoning. The other one, younger appeared to show no adverse effects at all. Veterinarians, just reporting that you've prescribed x amount of Trifexis to clients and never had a problem, is not a scientific study. If Elantra is admitting some of these symptoms as side effects, why aren't there more warnings? As a scientist who has dealt with the FDA, whose often onerous restrictions on releasing medications for human consumption sometimes border on ridiculous, the tone of their quotes on Trifexis sound like they are coming from a completely different organization. I encourage everyone to report their dogs symptoms and adverse reactions to FDA and Elantra. Just make sure to only report symptoms that did not exist prior to the consumption of Trifexis. Elantra now has a three in one pill - heart worm, fleas, and ticks, and yet my vet is refusing to stock it until there is more time to hear of any reports. That should tell you something besides the fact he is a very good vet.

Posted by: labguy | September 19, 2014 4:31 AM    Report this comment

We gave our two 4 yr old dogs trifexis today. One was fine and one got very ill. She couldn't even hold her tail up and when I picked her up she would only hold her nose in the air. She won't eat or drink and has slept all day. I'm praying she will recover. I will NEVER give her this poison again. This drug must be taken off the market before any more dogs are killed.

Posted by: Djdavis | September 16, 2014 8:25 PM    Report this comment

I noticed someone mentioning giving garlic for fleas to their dog. I read an article on poisonous plants, food, etc. by the ASPCA and garlic was mentioned along with many other items. It can cause some serious damage to a pet. Little did I know and am so glad I know now.

Posted by: mydogs2 | September 9, 2014 11:18 PM    Report this comment

My precious Gracie died this week and I think her death might be related to Trifexis. Of course, I can't prove this (and I may be wrong) but I think it's important to share this information so others don't go through the pain our family is dealing with now. After giving Gracie (a 10-lb poodle-chihuahua mix) Trifexis for the first time, she began lifting her head back (pointing her nose to the ceiling) and repeatedly doing a yawning motion with her mouth while her eyes were closed. Shortly after that, she vomited. A few hours later she had her first seizure. Our vet put her on phenobarbital to control the seizures. But a couple weeks later, the seizures returned. Then on Monday afternoon her seizures returned, but this time they continued. First they were an hour apart, then 45 minutes apart, 30 mins, 15, etc., and the vet couldn't do anything to stop them, so we had to make the heart-wrenching decision to put her to sleep. I can't express how heartbroken I am over losing my precious girl who was only 1.5 years old. As I said before, I can't prove that this is related to Trifexis, but Gracie didn't have problems prior to taking it. I will NEVER give Trifexis to another dog again, and I have told my friends to avoid it as well. I hope no one else has to go through this.

Posted by: AngieW | August 29, 2014 11:37 AM    Report this comment

An earlier commenter said "No drug company (or Vet!) wants to hurt pets. There is no financial reason and it is ridiculous to say that Vets are in on a conspiracy with drug companies to support unsafe products! We all get into this industry to help animals...and we like to base all our actions on the available scientific research."

The issue is not whether a drug company WANTS to hurt pets, but whether it cares more about the risks to your pets versus the bottom line of cashing in on a drug that's been in development for awhile, is now patented, and must be marketed in order to recoup the cost of research, development, profits for sharteholders/investors, and lost-alternative opportunities costs.

Posted by: letitia | August 12, 2014 12:06 AM    Report this comment

If you need to help your dog with fleas use garlic and debittered yeast powder in food 2x a day I used this on my Staff Harley for 15 plus years and never got fleas and he was on the beach in weeds and in the yard everyday!!!and also try Sentry Natural defense topical it works and is side affect free, used for Mosquitos too works like a charm they also have all natural shampoo works great!! I've worked in the pet field since 1976 grooming especially and use both products on my dogs and customers also love it. Good luck with your problem...

Posted by: Nyhluvsme | August 3, 2014 2:05 PM    Report this comment

My pet has been on Trifexis since February 2014. She has been having problems since she started using it. Dumb me I trusted my vet and continued giving it. She started becoming incontinent two months ago. I again took her to the vet and he prescribed meds to help with it. Never did it dawn on me that it could possibly be connected with the drug Trifexis because he prescribed it and I would naturally assume a competent vet would know the side effects and would have taken her off it. He did not. My dog Muffin has liver and kidney damage. She is very lethargic and is not eating very well. I am so angry I could spit! Is there a class action suit on this drug? I still have Muffin but she is very ill. This is just beyond me how vets who are usually animal lovers could do this to pets. I truly believe same as with M.D.'s they get kickbacks for prescribing this poison. Muffin in the last week since her last dose has loose, yellow stools with blood and black tarry appearance interspersed. I don't want to lose her. I rescued her after my husband passed of cancer. She has been my constant companion. Help please. I hope she can be saved.

Posted by: Muffin's Mom | July 30, 2014 4:49 PM    Report this comment

I have an 8 month old German Shepherd. I've been giving him this drug for a few months now. I have noticed he gets diarrhea and a decrease in appetite. He has vomited once or twice. I did give him the drug correctly (according to his weight) and had him tested for parasites (which he was clean) because I couldn't understand why my dog was sick. Eventually it would pass, but it didn't dawn on me that this drug could be giving him these side effects! I'm very unhappy with this drug! I can't believe all the dogs affected from it and why it's still being sold and recommended by vets!

Posted by: Lisa J | July 28, 2014 11:52 AM    Report this comment

My 2 year old Rottie has been on Trifexis for a year now and has no adverse reactions at all. I questioned giving it to him when I read about all the deaths and after doing extensive research, I learned that most of the deaths of the other animals occurred because of an underlying issue. He has not lost use of his legs, his bladder control, his appetite, his eyesight, his hearing, or any other bodily function. In fact, this is quite possibly the best all in one I have ever used.

Posted by: puptch | July 25, 2014 7:36 AM    Report this comment

My 5 yr old 1st lost urine control , then went Blind, & vomited Black & Black bloody diarrhea . My 11 yr old also lost urine control , went blind & had bloody diarrhea. Both died within a month of each other AFTER given Trifexis ... It is Cruel & inhuman treatment to KILL our family members. Now I hear the company has changed there name to continue murdering out pets. This needs to stop.
I lost my daughter ,my father , my husband & ,y mother all in 7 months. my 11 yr old was my daughters baby girl , I promised I would take care of for her & Trifexis KILLED HER . I hope the company & people who work for them & Vets that sold this garbage to use rot in .....

Posted by: DeathbyTrifexis | July 23, 2014 9:17 PM    Report this comment

My dog is a three year old mix hound and she lost the use of her back legs and can no longer walk due to the use of Trifexis this medication should be taken off the shelf so many dogs are dying getting sick or losing the use of their legs from this its horrible

Posted by: debpeir13 | July 17, 2014 8:03 AM    Report this comment

I was about to administer triflexis for the first time to my border collie today but I decided to do a quick search online first - I'm glad I did, I found multiple sites warning that dogs had died from this drug. I don't care how low the chance is that my dog will suffer ill effects, if there's even a small chance I am not taking that risk. I'm going to go down to my vet and get a refund for the triflexis. Question is, what can I use instead? I was only Prescribed triflexis because frontline and advantix no longer work (fleas are immune or resistant to the poison). The only alternatives where I live are triflexis and comfortis, both orally administrated (which I don't want to use after hearing about the dog deaths). Is there a natural remedy I can use? Otherwise the only option is to let him suffer and do a weekly bath to lower the numbers of fleas.

Posted by: Miss Cellany | June 9, 2014 5:06 AM    Report this comment

Reply to Patrick_67

Could you supply your site regarding collies please? I want to read the other post you mentioned.
Thank you!

Posted by: Karen N | May 30, 2014 3:02 PM    Report this comment

We put our six months poodle on Trifexis. He has been on it for six weeks. He has grown a red button on his right paw. He is jumpy. My ten year Jack Russel (female) has become solitary. I have never put these dogs or any previous dogs on any strong preventatives. After all my research, I am taking my dogs off Trifexis. The stats admit that Trifexis was released during the time of accumulation of paper reports of incidences and computer reports there was a problem getting the reports of findings combined because of fusing the two systems which left inadequate time for info to be stabilized because of the system compilations and the research lack.

Posted by: Page | May 30, 2014 11:45 AM    Report this comment

Response to Angelic

I am French and I have an important site on Collie.
A site mainly dedicated to the health problems of the breed.
A mutation in MDR1 gene makes Colley (and a dozen other breeds) sensitive to many chemical molecules, including Ivermectin.
MDR1 protects the brain (CNS) against many toxic molecules (xenobiotics).

I launched an alert on 14/08/2011 on Comfortis and active molecule that is spinosad.

The findings suggest that spinosad, by inhibiting MDR1 action at the blood-brain barrier, increases the risk of neurotoxicity for many molecules (xenobiotics).

The TRIFEXIS uses spinosad + milbemycin oxime .
However, the milbemycin is a molecule of the same family as Ivermectin. The milbemycin also interacts with MDR1 .

Perhaps many accidents could be explained by this action that the TRIFEXIS can produce at the blood-brain barrier.
All adverse effects are neurological signs: vomiting , depression, lethargy , anorexia , trembling / shaking , ataxia , seizures , hypersalivation

I will shortly issue a warning about the TRIFEXIS because these two molecules bound to MDR1 .
The risk of unintended interaction with other chemicals controlled by MDR1 molecules are important. And, especially as spinosad has a long duration of action.


Posted by: Patrick_67 | May 10, 2014 3:23 PM    Report this comment

Hi, I found the comments very interesting. We have used Frontline for years with no adverse affects. I wonder if it makes a difference whether the dog is large or small? I am in animal rescue and I have always adopted large dogs. Right now I have an American Rottweiler and a yellow lab, both neutered. It seems that the seizures and other complications, even death, are in small dogs. Since I have used Frontline for years, on other dogs that have crossed over from old age and NEVER had a problem, I am sticking with it. We use Heart Guard for heartworms. Our Vet recommends year round protection but here in Michigan there are no mosquitoes or fleas in the winter. (especially THIS winter, 2014) I also feel that it gives my dog's liver a break for a few months. Money is not a factor. Every March or April we have the blood test just to be sure and then treat them until winter rears it's ugly head again. I NEVER BUY ANYTHING THAT WILL BE CONSUMED FROM CHINA!!!

Posted by: Unknown | February 3, 2014 6:02 PM    Report this comment

I believe my own eyes and I had my Gizmo (Yorkie) given a clean bill of health by a Vet ,on my way out I was handed a Trifexis tablet to give him. He was acting fine till the night I gave him that tablet,as soon as I did he ran acting funny and vomitted 3 times. Next day wasn't acting right,became lethargic,couldn't eat,or drink,couldn't move his back legs.Next stage was blood in his stool,seizures etc.The pain that he suffered was horrible, I even had him in a Vet Hospital on IV etc. Still I couldn't save my precious baby, I still hurt and will never forget that what I thought was the right thing ,give him a pill from a Vet and now he is gone, Trifexis shouldn't have been put on the market without more testing.The people from Elanco are still denying what is going on ,,how can they sleep at night. Do people really think we are pooring our hearts out on face book for nothing.. Think the video's on there aren't real,,,give me a break ,,we are doing these in memory of our precious little ones who aren't hear and don't have a way of standing up for themselves.

Posted by: angelic | February 1, 2014 5:36 PM    Report this comment

Thank you for the balanced report. A restrained and thoughtful approach is hard to come by these days.

Posted by: wollfie | December 27, 2013 2:30 PM    Report this comment

I'd like to see a report on heart worm pills like the report on food.

Posted by: carolthequilter | December 25, 2013 8:02 PM    Report this comment

I don't think I'm paranoid, but I do think we are at "war" w/China. The more we buy from that country, with their care-less attitude toward other's health and well-being, the more they win. I will not knowingly buy products made in China and I am careful when reading labels. I will pay more and buy USA made AND assembled.
A few years ago, I was purchasing garden rocks and found some real beauties for my garden. As I was about to pay, the clerk mentioned that they were imported from China. That stopped the sale. Why should I care about rocks that certainly would not be ingested? I care because I will not support a society that does not support the human/animal condition. Read those labels!

Posted by: Rochelle | December 25, 2013 8:38 AM    Report this comment

I have yet to find a "satisfactory" flea treatment.

The old 'washes' tended to be very limited, especially when used on dogs with a dense undercoat. They also tended to make the dogs sick.

The flea collars make ME feel sick heaven's knows what they do to dogs that are wearing them.

Swimming in the ocean works well -- for dogs that WILL go in the water and saturate themselves to the skin.

Initially fipramil seemed to do a wonerful job, but recently I've found that a couple of weeks after applying the various spot-ons for ticks, we have a flea plague :-(

So I use Spinosad. So far with no ill-effects (except freedom from fleas! :-) But I do not think that I would use it regularly.

From the reported problems I've heard here it seems to be due to long term regular use.

Posted by: Jenny H | December 25, 2013 2:23 AM    Report this comment

Thanks for writing an interesting article with such a balanced view. It is true, we need to keep things in perspective. In Australia we have Comfortis and Panoramis, which also contain Spinosad. Initially my clinic was reluctant to recommend the product, as there already seemed to be so many good flea treatments available with proven track records. More and more clients kept coming in and asking for Comfortis, as they had bought it elsewhere online and loved it. Eventually we caved, and have so far had no adverse events reported.

That being said, I think it is definitely true to say that no drug is 100% safe, and unfortunately the same can be said for 'natural' things too. A pet or human can have an adverse reaction to anything, whether that be a so-called natural thing such as something in their food, a herb, a vitamin, a plant, or an essential oil and I think we need to keep any reaction in perspective. I could develop a severe anaphylactic reaction to an insect bite. If that happened 2 hours after I administered a flea treatment to my pet I would definitely blame the flea treatment. That is human nature, but it is not science.

No drug company (or Vet!) wants to hurt pets. There is no financial reason and it is ridiculous to say that Vets are in on a conspiracy with drug companies to support unsafe products! We all get into this industry to help animals...and we like to base all our actions on the available scientific research.

One of the most common 'natural' products I see as a vet used inappropriately is Tea Tree oil. This can be very toxic if ingested (such as when your pet grooms), and is contained in many products, such as animal shampoos for its antibacterial properties. Usually the concentration is minimal, so it is relatively safe, but of course that concentration is also completely ineffective and will not kill bacteria at all.

I think with all the information on the internet we are all wise enough to know that we can't trust everything we read. A very well-meaning person on the internet claiming to have a 'natural' solution to fleas has essentially a study group of one or two on which to base their safety data. Administering garlic to your pets is toxic, do not use this a flea preventative! If you want to use something safe, use good old fashioned vacuuming, sunlight and washing of bedding at more than 60 degrees Celsius before you spray your pet with anything weird or give them a 'natural' product.

Posted by: Unknown | December 24, 2013 11:47 PM    Report this comment

There is NO safe chemical product. There are plenty of safe, all natural products that will repel and/or kill fleas, lice, mites, pests on our pets. Our dogs picked up lice from a trip to a groomer. No way did we have time to shampoo and nit pick them daily so I searched online and found that neem seed oil kills pests and their eggs. Works for fleas, lice, mites and more. This website has the information: www.discoverneem.com. We added 1 oz of raw neem seed oil to 1.5 oz of liquid peppermint castile shampoo; kept it all sudsy on the dogs for 10-11 minutes, rinsed well. Repeated that 2 more time every 7 days. After the first shampoo, they weren't itching any longer. It killed all the buggers and was safe for the dogs. Be sure to protect their eyes with either a drop of mineral oil or Puralube eye ointment in each eye before lathering them up. The website has instructions on making a natural spray that works as a repellant and we use that when the dogs go anywhere they could pick up critters. Neem oil smells a bit like garlic so we add either geranium, lemon grass or citronella essential oil to the spray mix; smells so nice then. It really works, they haven't had any fleas or other pests. To put it on the head/face area, we spray it on our hands and rub on their fur. You need to make the shampoo mix fresh each time as it only lasts for 8 hours.

Years ago, my sister put a topical flea product on her small dog; she didn't know they were toxic and her stupid vet told her it was safe. 2 hours later, her dog had a seizure. She calls the vet who says it can't be from the product, must be a coincidence...but he tells her to bathe the dog really well and then bring him in. The dog has never had another seizure and my sister learned the hard way that 1)no chemical is safe, no matter who says it is; 2) conventional vets don't know much.

Posted by: YorkieMom | December 24, 2013 2:41 PM    Report this comment

About 6 months ago a friend working in a repro clinic in FLorida mentioned that Trifexis was the cause of neonatal deaths and some other repro problems and was not recommended. About that time a 9 month old terrier pup I had sold was obviously showing signs of Failure to Thrive and I mentioned Trifexis - turns out that she was on it so I asked that something else be given - within two months she had gained 2 pounds and her coat was beaching thicker and glossy.

Posted by: carol o | December 24, 2013 11:11 AM    Report this comment

China rears it's ugly head again.
I cannot believe people are so dumb to keep buying products from China.

Posted by: Norm Starr | December 24, 2013 10:38 AM    Report this comment

A grain of salt? If you love your pets, avoid poisoning them with this Toxic drug! Try proving to Elanco that your dog was harmed. All you can do is prove what it isnt... They will still say maybe its your water?? Nice try, I only give her bottled water.

The reports are very vague as they ask for symptoms before the final diagnosis is made. The updates are not reported. Sadly your dog will suffer long term effects of this poison, providing they make it. I still have my darling, but not because they helped me. She will have permanent damage as many will. Your vet listens to the sales people at Elanco, Trifexis is made in China. Be safe not sorry!

Posted by: Salli J | December 24, 2013 10:19 AM    Report this comment

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