Dog Toothpaste

What's in this stuff, anyway? And is it really necessary? Here's what to look for and what to look out for when buying dog toothpaste.


The phrase “toothpaste for dogs” sounds like the punchline to a joke – the epitome of a ridiculous product that’s not necessary but is being marketed by an avaricious industry looking to profit by foisting useless gear on unsuspecting dog owners. I’m sure that some comedian somewhere could get a good five minutes of laughs out of the topic. 

The truth is, though, that toothpastes that are formulated for pets are helpful. They improve the mechanical effect of the toothbrush, their abrasive ingredients improve the plaque-removing effect of brushing, and their enzymatic ingredients help reduce the population of bacteria present in a dog’s mouth. 

Why is this so important? To prevent a cascade of ill effects for your dog. Bacterial overgrowth, also referred to as “biofilm,” causes infection and inflammation when it accumulates below the gum line.  Biofilm becomes plaque; plaque promotes the formation of tartar, and both substances give the bacteria more surfaces to cling to and opportunity to proliferate under the gums. And bacteria can not only contribute to bad breath, but also contribute to periodontal disease, which has been linked to severe deleterious effects throughout the body, including the liver, kidney, heart, and lungs. Studies have established a link between canine dental disease and diabetes, “distant neoplasia” (gastrointestinal, kidney, pancreatic, and hematological cancers), chronic inflammation, and early mortality.  

To recap: It’s critically important to help your dog keep his teeth clean!


We’ll start by mentioning that there is an organization – the Veterinary Oral Health Council (VOHC) – that examines any applicable research studies that might prove the effectiveness of various veterinary dental products as they relate to one of two possible claims: “Helps control plaque” and “Helps control tartar.” Interestingly enough, only one pet toothpaste on the market carries one of those claims: Petsmile Professional Pet Toothpaste, which earned the VOHC seal for “Helps control plaque.” That was enough to make this product our favorite, despite the fact that it’s way more expensive than its competitors. 

The one thing that all pet toothpaste manufacturers seem to agree on is that these products should contain an abrasive ingredient. If that sounds alarming, relax: Abrasive ingredients make up at least 50% of human toothpastes! 

Commonly used abrasive ingredients include calcium carbonate, sodium bicarbonate (also known as baking soda), sodium chloride (salt), various forms of silica, and dicalcium phosphate.

Pet toothpaste should have a flavor that’s (at a minimum) not aversive to dogs and (at best) pleasant. It’s generally accepted that most dogs don’t particularly enjoy minty flavors, so you’ll see most pet toothpastes flavored with either an artificial sweetener, an artificial peanut butter, or meat “flavor.” We tasted every toothpaste we included in this review and not one, in our opinion, tasted like either meat or peanut butter. Some were vaguely sweet.

That said, dogs have far fewer taste buds than we do – about 1,700 compared to about 9,000 in humans – so, as long as the toothpaste doesn’t taste bad, perhaps the taste isn’t that important.  

It’s well established that the mechanical action of brushing is the most effective home care that owners can provide to their dogs. But the use of products that contain antimicrobial agents can increase the efficacy of brushing. Antimicrobial agents reduce the bacterial population in the dog’s mouth and reduce the formation of the biofilm which, left undisturbed, would begin to form plaque and, eventually, tartar. 

If your dog resists the brushing process, and you’re able to get only a little antibacterial toothpaste into his mouth, don’t despair. Several studies have indicated that the simple introduction of antimicrobial toothpastes into a dog’s mouth – even without the mechanical brushing action – is more beneficial to the dog than no action being taken at all. 


Here’s a great way to choke, smother, or poison your dog – by using a toothpaste with a foaming agent. Don’t do this!
Photo Credit: Oleksii Stasiuk/

We hope that all dog owners are aware that they shouldn’t use toothpaste that is formulated for humans when they brush their dogs’ teeth. There are a number of ingredients in human toothpaste that are problematic – and even downright toxic – for dogs. Some of the ingredients are no healthier for humans to swallow than dogs, but you can tell humans not to swallow it, and they (usually) won’t. (Children’s toothpastes contain less fluoride than adult toothpaste because they are less able to follow this instruction than adults.)

Almost all human toothpastes contain fluoride, an effective anti-cavity agent, but it’s not in any pet toothpastes, as dogs are particularly sensitive to this agent; it’s considered a major toxin for them. 

Xylitol is a sweetener that’s found in many human toothpastes, but is highly toxic to dogs and is never included in pet toothpaste.

Humans seem to love the foaming action of our toothpastes; it seems to help distribute the cleansing, refreshing agents all around our mouths. But given that we don’t want our dogs to swallow the toothpaste – and they have no way of knowing that, or of rinsing their mouths without swallowing – foaming agents should not be included in a pet toothpaste. 

Sodium lauryl sulfate is the most commonly used foaming agent in human toothpastes. It also offers detergent properties (binds with impurities and helps them be rinsed away) and mild antibacterial properties. However, it can cause gastric upset in dogs – and its foaming action is more trouble than its worth in a dog’s mouth. We found it included in just one of the 10 toothpastes we reviewed (Nylabone Tartar Control Pet Toothpaste; see next page). 

Need Motivation to Break Out the Brush?

I doubt that anyone enjoys brushing their dogs’ teeth; with the most cooperative of dogs, it’s a minor inconvenience, and at worst, a major hassle. But if you need a little motivation to convince you to put this chore on your to-do list, consider these dental-health facts:

✔ People who brush their dogs’ teeth regularly are more likely to notice problems such as tooth fractures or chipped teeth, loose teeth, gum inflammation, or growths in the mouth. Early detection of these problems is essential to successful treatment (especially of oral tumors).  

✔ Reducing the amount of bacterial plaque at and below the gum line of the teeth is critical for preventing the development of gingival inflammation and periodontal disease. Regular brushing has been shown in many studies to be the most effective means of reducing the amount of plaque on dogs’ teeth; it’s considered the gold standard for maintaining dental health. In fact, one (human) study found that professional cleanings were of little value without regular home care (brushing). Multiple studies have shown that bacterial plaque begins to attach to the tooth surfaces again within 24 hours of cleaning. 


We’re not picking any favorites other than the Petsmile product (with its VOHC seal). Use of any of the products will be better than none. We’d recommend trying various products and seeing which ones your dog accepts best. 

That said, if your dog already has a significant tartar accumulation on his teeth, we’d definitely suggest a product with a tartar control agent (see the list of ingredients and what they do on page 21). Otherwise, just buy a pet toothpaste, introduce it to your dog as soon as possible, use it regularly, and monitor the appearance of his teeth and gums as time goes by. We think you’ll be amazed at the improvement you will see with regular use of any product. 


Product Name
Maker Information
Price/SizeIngredients Comments
Arm & Hammer Completecare Enzymatic Toothpaste
(855) 430-8100
$6, 6.2 ozSorbitol, water, hydrated silica, calcium carbonate, polysorbate 20, tetrasodium pyrophosphate, cellulose gum, sodium chloride, flavor, sodium bicarbonate, zinc gluconate, proteases, thymolNote that Arm & Hammer name is licensed by Fetch 4 Pets; product not actually made by Arm & Hammer. Flavors: Beef, banana mint, chicken, peanut butter, vanilla ginger.
Freshbarks Enzymatic Toothpaste
Phone # not made available
$25, 7 oz (3.5 oz per tube)Glycerine, aloe, pectin, neem oil, grapefruit seed extract, baking soda (sodium bicarbonate), glucose oxidase (enzymes), natural flavorsSold only in a pack of two tubes with a unique two-headed toothbrush. One flavor. We’re not crazy about companies that can be reached only via email and that seem to take pains to hide their business location (in this case, the Netherlands).
Nylabone Tartar Control Pet Toothpaste
(855) 273-7527
$4,2.5 ozSorbitol, hydrated silica, vegetable glycerin, purified water, ascorbic acid phosphate, sodium hexametaphosphate, magnesium aluminum silicate, sodium lauryl sulfate, titanium dioxide, natural flavor, cellulose gum, tetrasodium pyrophosphate, sodium benzoate, potassium sorbate, sodium copper chlorophyllinOriginal and peanut butter flavors. We tried the original; we can’t tell you exactly what it tastes like. It’s vaguely sweet and sort of toffee-flavored. “Tartar control” in name is supported by more anti-tartar agents in the ingredients than some of the others.
Nutri-Vet Enzymatic Toothpaste
(877) 729-8668
$3, 2.5 oz.Purified water, sorbitol, glycerin, hydrated silica, dicalcium phosphate, xanthan gum, artificial flavor, sodium saccharin, sodium benzoate, glucose oxidase (Aspergillus niger)The box indicates “Chicken Flavor Paste,” but there is that vague, sweet toffee flavor again. Price seems like a bargain.
Petrodex (Sergeant’s Pet Care) Enzymatic Toothpaste
Website not made available
(800) 224-7387
$9, 6.2 ozSorbitol, dicalcium phosphate, water, hydrated silica, glycerin, poultry digest, dextrose, xanthan gum, acidified calcium sulfate, disodium phosphate duohydrate, potassium sorbate, citric acid, sodium benzoate, Aspergillus niger fermentation extractAvailable in peanut butter and poultry flavors. We tried the poultry flavor, which, likely due to an actual poultry-originated ingredient and also its unappealing (to humans) brown color, we didn’t enjoy as much as our test dog did.
Petsmile Professional Pet Toothpaste
(800) 784-7645

$27, 4.5 oz.Water, glycerin, dicalcium phosphate dihydrate, citric acid, Calprox (calcium peroxide), flavor, sodium benzoate, EDTA, cetylpyridinium chloride, carbomer, potassium hydroxide, xanthan gumThis is the only product on our list that carries the seal of the Veterinary Oral Health Council for plaque inhibition – that’s actually a big deal (and justifies the high price); it’s been proven to work. Available in “Rotisserie Chicken” and “London Broil” flavors. We tried the latter; it was inoffensive but didn’t taste like steak. The dogs didn’t object.
Vet’s Best Enzymatic Toothpaste
(800) 690-9908
$5.50, 3.5 ozGlycerin, aloe, pectin, neem oil, grapefruit seed extract, sodium bicarbonate (baking soda), glucose oxidase (enzymes), and natural flavorsVet’s Best offers a money-back guarantee if you are not satisfied with the product. This is the most “natural” product included here. Comes in one unspecified flavor; tastes like aloe but also slightly soapy. No objections from the dogs.
Vet’s Preferred Advanced Enzymatic
(855) 270-3578
$13, 3 oz.Water, silica, sorbitol, peanut butter flavor, saccharomyces enzymes, sodium carboxymethyl cellulose, polysorbate 20, xanthan gum, potassium sorbate, sodium benzoateVet’s Preferred offers a money-back guarantee if you are not satisfied with the product. Available in one flavor: peanut butter. Our test dogs are good sports but we really didn’t like the taste of this.
Virbac C.E.T. Enzymatic Toothpaste
(800) 338-3659
$10, 2.5 ozSorbitol, purified water, dicalcium phosphate anhydrous, hydrated silica, glycerin, poultry digest, dextrose, xanthan gum, titanium dioxide, sodium benzoate, potassium thiocyanate, glucose oxidase, lactoperoxidaseVirbac described this a “dual-enzyme system toothpaste” and it does, in fact, contain multiple antimicrobials. Comes in beef, malt, poultry, seafood, and vanilla mint flavors. We tried the poultry; the dogs liked it.
Waggletooth Dental Toothpaste
(800) 569-8616
$16, 4 oz.Water, glycerin, xanthan gum, peppermint oil, salmon oil, grapefruit seed extract, rosemary oil, thyme oil, dried Bacillus subtils fermentation product, dried Bacillus licheniformis fermentation product, and grape seed extractThis product was developed by a dentist (rather than a veterinarian), and it takes a novel approach with the “targeted oral probiotics,” herbal extracts, and essential oils in its formula. One flavor; tastes just like you would imagine a product that contains peppermint and thyme would taste.


The following are ingredients that are commonly found in pet toothpastes. They are listed alongside their mode of action – or purported mode of action – the reason they are presumably included. Not all ingredients used by various manufacturers have proven to perform the tasks for which they were included in this application.
AloeAntibacterial, anti-inflammatory
Ascorbic acid phosphateBiofilm inhibitor
Calcium carbonateAbrasive
Calcium peroxideWhitener
CarbomerGelling agent
Cellulose gumThickener, stabilizer
Cetylpyridinium chlorideAntiseptic
Dicalcium phosphateAbrasive, tartar control agent
EDTA (edathamil)Reduces biofilm
Glucose oxidaseAntibacterial, helps break down plaque
Glycerin (also known as glycerine and glycerol)Humectant (retains moisture, keeps product from drying out), improves gel texture
Grapefruit seed extractAntibacterial
Grape seed extractAntibacterial
Hydrated silicaAbrasive
Neem oilAntibacterial
PectinThickener, gelling agent
Polysorbate 20Surfactant (reduces a liquid’s surface tension, thereby increasing its spreading and wetting properties); emulsifier (stabilizer, keeps product from separating)
Poultry digestFlavoring agent
Potassium hydroxideNeutralizes the acidic pH imbalance caused by other chemicals used in toothpaste
Potassium sorbatePreservative
Potassium thiocyanateReduces gingival inflammation and supragingival plaque
Saccharomyces enzymesAntibacterial
Sodium chloride (salt)Abrasive
Sodium benzoatePreservative
Sodium bicarbonate (baking soda)Abrasive, mild disinfectant, fungicide (may change a dog’s urinary pH)
Sodium carboxymethyl celluloseStabilizer
Sodium copper chlorophyllinAntimicrobial
Sodium lauryl sulfateDetergent
Sodium saccharinSweetener
SorbitolSweetener, thickener, humectant
Tetrasodium pyrophosphate Tartar control agent
Titanium dioxideWhite pigment, thickener
Xanthan gumThickener, stabilizer (keeps ingredients from separating)


  1. I have found SORBITOL to cause gas and other digestive upset in myself and avoid it always.
    I do not understand the overwhelming need for it to be in canine toothpaste and I will not use any brand that contains it. Your articles and research Nancy are excellent and I love reading your informative articles. Please though, would you kindly look into sorbitol as an gastric or intestinal irritant, especially for any dog that already has a fussy digestive system.

  2. Thanks for this useful information. I have found that beyond being helpful, toothpaste has another use. May not qualify as a “good” reason to use toothpaste in terms of oral health, but it’s a practical “good” reason–toothbrush time is yummy. All dogs we’ve ever had and brushed their teeth liked it and will lick it off your finger, off the toothbrush, etc. We’ve always used the CET Enzymatic toothpaste (poultry flavor) and the dogs really like it and it seems to do a pretty good job.

    • Janet, I use CET on my 14 1/2 year old miniature schnauzer. I try to brush her teeth every evening when it is time for her meds. When I talked to my vet for her annual teeth cleaning he told me that due to her age and the anesthetic agent used when they clean their teeth he was not comfortable cleaning her teeth anymore. She has had her teeth cleaned professionally for years. No more. Yes, she is old and I try to be very careful with her. I have read where schnauzers tend to have a tendency to dirty teeth unless they are really taken care of. Just thought I would let you know I also use this toothpaste in spite of the price.

  3. I have been using PetzLife tooth paste for a few years and am pleased with the results. It was not part of the 10 reviewed. I have enjoyed all these article and have subscribed to Whole Dog Journal since the first year.

  4. Ingredients in PetzLife Toothpaste: Distilled water, grain alcohol, wild salmon oil, xanthan gum, peppermint oil, grapefruit seed extract, grape seed extract, rosemary oil, thyme oil, neem oil.
    My Shelties don’t mind having their teeth brushed.

  5. Dogs are not supposed to have grapes, currants or raisins because of their toxicity. Why would grape seed extract in a canine toothpaste be a good idea? Wouldn’t that make it toxic to the dog?

    • I googled it and grape seed extract is not toxic in small quantities unlike grapes.Often an extract from a seed is different than the fruit or vegetable it comes from.Many years ago I gave a dog some grape seed extract for an eye problem and he was fine .You would never for example eat rhubarb leaves but the stalk is fine so plants and fruits often have different toxicity levels in their seeds, leaves etc.

  6. My dog does well with the “Vets Best” when he was puppy I tried the “petrodex” and it went bad very quickly -the company was unhelpful.As a result I always keep his toothpastes in the fridge. We have a tube of the Virbac in the fridge but I never use it- he does well on the Vets Best. He had a gastrointestinal operation when he was a year old so I am careful about what he ingests.He loathes being brushed but allows me to brush his teeth.I don’t always do a prolonged brushing and I have sometimes let a week or two go between brushings but I find a little is better than nothing.The vet once told me his teeth were very clean so I guess even a haphazard approach works and I think the enzymes help .I do find I have to replace the toothbrushes they get gunky.

  7. Thank you for such a great article! Very informative. I had my shih-poos teeth cleaned the summer before we were all quarantined for the covid outbreaks in 2020. Vet told me he really wanted me to try to brush his teeth at home. He was 7 then. I tried & tried but it is so difficult because he hids. Well I found the Petsmile Professional Pet Toothpaste on Amazon & decided to give it a try. He likes it okay. I was starting to see build up but noticed just last night his teeth are starting to look better. How I got him started, after wrestling him down didn’t work, was I put this tooth past on my finger & let him lick it off. Then started trying the brush I got for pets, small end. Now at least he sits without me having to have my husband hold him down. Anyway thanks for this article! Really appreciated it! Glad our tooth paste pick was on there!!

  8. Great article – really useful details! I have brushed all of my dogs’ teeth for at least 20 years using an electric toothbrush and Petrodex. I introduce them to it at 8 weeks of age, and they love it. They line up in order (oldest to youngest, who have to learn patience). This is super easy to teach, and for me has eliminated any need for professional cleanings.

    • Your the only other person i have heard of also using non conventional toothbrush . I use sonic care on my Sheltie the head is thin and reaches to the back teeth really well. I have found out that it’s easier if you just hold the toothbrush in one location at a time and do not press against the tooth just let the toothbrush do the work like it’s suposed to. Hold the whiskers so they don’t get tickled and don’t let the stem of the toothbrush touch the teeth ( doesn’t like it TOO mush vibration ) Just like anything else introduce with common sense
      Happy Brushing

  9. Tooth brushing is ONLY necessary for dogs fed and unnatural and strarchy diet — or with malocclusion or with weaken in the womb through poor diet of the dam .
    Leave out the ‘KIbble’. Fed raw meaty, no fatty, spongey bone daily. it is WELL worth the cost

  10. I have a large Collie and discovered that his teeth were improved when I switched from a toothbrush made for dogs to a soft, quality toothbrush made for humans. His teeth are large and the human toothbrush was more effective in crevices (using the advanced technology of rotating bristles).